Propecia drug Reviews, Cost, Result, and Dosage (Hair Growth Pill)
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Propecia drug Reviews, Cost, Result, and Dosage (Hair Growth Pill)
Propecia Drug

Propecia (Finasteride) drug is used in the treatment of hair loss, popular worldwide. It is the Propecia brand name that makes Finasteride tablets to protect and regrow hair. Generally, common problems seem in both the gender (male/female), related to hair loss. Sometimes it happens due to dust & impure water, a few people have genetic issues. Also, you can buy Propecia online.

“Propecia is the treatment of male pattern hair loss, Only For men.”

According to studies, 85% of men are quite thin hair, and about 25% of men who suffer from male pattern baldness begin the painful process before reaching the age of 21 years.

The chemical from which Propecia made is very useful for the scalp and hair, now check out the look on the description.

Reason for Propecia popularity

Finasteride (active ingredient) present in Propecia tablets, which is a synthetic 4-asteroid compound. This compound is considered an inhibitor of steroid Type II 5α-reductase. 5α-reductase is an intracellular enzyme, which converts the androgen testosterone into 5α-dihydrotestosterone (DHT).

“N-tert-Butyl-3-oxo-4-aza-5α-androst-1-ene-17β-carboxamide is the chemical name of finasteride”

Empirical formula= C23H36N2O2

Molecular weight= 372.55

Melting point= 250°C

Propecia film-coated tablets containing 1 mg of Finasteride and lactose monohydrate, microcrystalline cellulose, pregelatinized starch, sodium starch glycolate, hydroxypropyl methylcellulose, titanium dioxide, magnesium stearate & more.

Before purchasing this medicine check out the review of this medicine, which are mentioned below:

Propecia drug reviews

Propecia benefit after 1 year
Propecia benefit after 1 year

Mark (LA, Arrow Highway):

“ I’m 35 year old America male, I’ve had No side effects from this medicine, I’ve been using this drug from 3.5 year. In starting a few months, I don’t feel any changes in my hair from last 3-4 months. But after 6 months, I’ve gained much new hair.”

Charlie (Edinburgh, Albany Street):

“I am disappointed due to bald spots when I was 23 year. Tried rogaine but don’t get the benefit. At last, I choose Propecia, from a disappointed mind. Really, I feel amazed, within six months I started seeing results.”

Oliver (Belfast, Abbeydale Crescent):

“My son takes this medicine since he was at 19 year. I am really thankful for this medicine, believe his hair has stopped thinning.”

Robert (Chicago, East ida B.Wells Drive):

“I just try this product after many experiments, for stopping my hair loss with some regrowth. Took for nearly twenty years. detected some diminished sexual drive once a couple of years however not enough to be a tangle.”

But a regular prescription dose of this drug is very effective and I used to be obtaining older and thought that might be an element. Then someday I used to be mortified to seek out I couldn’t maintain Associate in Nursing erection or climax throughout intercourse with Associate in Nursing exciting and far younger girlfriend. I ended taking the drug and in concerning sixty days matters had greatly improved so that I even have a sex life once more. I’m hoping it’ll still recover.”

Propecia drug cost & storage

Propecia is an inexpensive drug used in the treatment of hair loss and benign prostatic hyperplasia (BPH). The lowest price for Propecia is around $2.70, the average retail price of $65.60.

Detail of price and offer for 30 tablets of Finasteride 1 mg.

Provider of medicine have there a different scale of pricing, Checkout the list:

ProvidersFinasteride Price
Safeway$79
CVS Pharmacy$77
Target (CVS)$77
Rite Aid$94
Walgreens$81

Variation in price 2019

DateAvg. Cash Price
May 2019$59.80
Apr 2019$58.80
Mar 2019$58.20
Feb 2019$57.08
Jan 2019$55.22

Storage:

  • Keep the drug at room temperature between 59°F to 86°F (15°C to 30°C).
  • Moisture free (Keep Propecia drug Dry).
  • Try to keep the drug in a closed container.

Propecia Drug Result

Propecia uses for the treatment of hair loss, now you are going to know about the tips which will help to get quick hair growth. Only made for males and approved by the FDA, in trend from 1997 as a treatment for hair loss.

80% of the men who used Finasteride in the clinical trials didn’t experience any more hair loss, 66% of them regrow hair over an extended period.

Finasteride doesn’t work overnight, takes time, and requires consistent usage for the best results of propecia. In the process of regrowing hair, we can’t see the major results until they’ve taken Finasteride for at least a year or more.

1. Give a daily massage to your scalp

According to Japanese researchers, daily four- minutes massage over the hair increases the blood circulation and help to stimulate hair growth and thickness.

2. Take biotin supplements

Vitamin B complex, ensuring that your hair, fingernails, and skin stay healthy. Lacking biotin hair of growing weaker and more slowly than usual

3. Combine Finasteride with minoxidil.

Along with Finasteride, it’s the only other product approved by the FDA. According to observation on 984 men, various stages of a male pattern have observed 5% minoxidil to their balding spots twice a day.

Side effects of Propecia

Some of the major Propecia side effects are as follows:

Propecia side effects
Propecia side effects
  • Decrease blood Prostate Specific Antigen (PSA), an increase in the following PSA levels from their lowest point may indicate the presence of prostate cancer and it should be evaluated,
  • Weakness/Helplessness,
  • Loss of interest in sex,
  • Orgasm problem,
  • Swelling in body,
  • Weakness/dizziness,
  • Headache,
  • Runny nose,

The quick doctor consults because it is a symptom of male breast cancer. If you are suffering from:

  • Breast lumps,
  • Tenderness with breast pain,
  • Nipple discharge,
  • Changes in male breast size,

Common Side effects:

  • Abnormal Premature Ejaculation Causes (abnormal ejaculation),
  • The problem of having an orgasm (the climax of sexual excitement),
  • Not a feeling of any excitements,
  • Impotence,

Propecia drug dosage & Precautions

  • Propecia drug can be taken with or without meals (empty stomach).
  • Daily use of this drug for three months or more is necessary, to check out the results.
  • Don’t recommend this pill to anyone without the advice of a doctor.
  • Don’t take this drug more than recommended.

Precautions

  • Before taking medicine, tell your doctor about any other allergies, you are suffering from.
  • Check your heart and blood health before taking drugs.
  • Protect from child/don’t throw medicine anywhere in a public place or room.
  • Avoid giving this medicine during pregnancy.

Complications And Warnings of Propecia

Should Not Take By Women

Propecia drug is not meant for treatment in women. Therefore women should not touch broken or crushed tablets of Propecia. Most apparently when a woman is pregnant or may possibly be pregnant. Because the chance of absorption of finasteride (Propecia) may cause the subsequent possible danger to a male fetus.

However, Propecia medicines are well coated. Therefore it can prevent your contact with the active ingredient while normal handling of this drug. Besides that, the tablets must have not been crushed or broken. Although you should aware of use In specific populations, indications, usage, contradictions, and how supplied to patient information.

Impacts On PSA (Prostate-Specific Antigen)

Although in some clinical studies of Propecia known as finasteride 1 mg, in the 18-41 years of the age group of men. In that study, the mean value of serum prostate-specific antigen (PSA) is reduced from 0.7 ng/mL at baseline to 0.5 ng/mL in a 12 months period of time.

Moreover, in clinical studies with Proscar known as finasteride, 5 mg. When this drug is used in older men who have benign prostatic hyperplasia (BPH). Then the PSA levels may be decreased by approximately 50%. However, some other studies with Proscar revealed that it can also be caused some reductions in serum PSA in the appearance of prostate cancer.

Although these conclusions must be taken into account for proper analysis of serum PSA when estimating those men who treated with finasteride. Therefore any confirmed progress from the lowest PSA value while on Propecia may signal the presence of prostate cancer.

In addition, it must be evaluated, even if PSA levels are still inside the normal range for those men who are not taking a 5α-reductase inhibitor. Besides that, the non-compliance to treatment with Propecia can also affect the PSA test results.

Chance Of High-Grade Prostate Cancer

Although it can increase the chance of high-grade prostate cancer with 5α-reductase Inhibitors. During the study in men, the aged group of 55 and over with a regular digital rectal examination and PSA ≤3.0 ng/mL at baseline using finasteride 5 mg/day. That is 5 times the dose of Propecia.

This dose in the 7-year Prostate Cancer Prevention Trial known as PCPT had an enhanced chance of Gleason, that score 8-10 prostate cancer. However, similar results were inspected in a clinical trial of 4-year placebo-controlled with another 5α-reductase inhibitor known as dutasteride.

However, the 5α- reductase inhibitors can increase the chance of improvement of high-grade prostate cancer. Whether the impact of 5α-reductase inhibitors to decrease the volume of the prostate or study-related circumstances, affected the outcomes of these studies, which has not been established.

Higher Risk For Male Fetus

Physicians must need to inform patients that those women who are currently pregnant or can possibly be pregnant in the coming future must not handle split or fragmented Propecia tablets. Because of the feasibility of incorporation of finasteride into the skin and the subsequent potential risk to the fetus of a male.

Although such tablets of Propecia drugs are normally coated. So that it can also prevent such contact with the vital ingredient of this drug during ordinary handling. But it provided that the pills have not been crushed or broken.

Besides that, if a pregnant woman or a potentially pregnant woman get in touch or contact with any of the broken Propecia tablets. Then, the touched or contact part or skin of the body should be immediately washed with water and soap

Increased Risk Of High-Grade Prostate Cancer: Patients must be notified that there was an increment in high-grade prostate cancer in such men treated with 5α-reductase inhibitors that were indicated for BPH treatment when compared to those patient treated with placebo in studies looking at the use of these drugs to prevent prostate cancer.

Some More Instructions

Physicians must instruct all of their patients to promptly report any differences in their breasts such as pain, lumps, or nipple discharge. Al these breast changes also including tenderness, breast enlargement, and neoplasm have been reported.

Nonclinical Toxicology

Impairment Of Fertility: Well, carcinogenesis, mutagenesis, and impairment of fertility may cause by this drug. However, no proper evidence of a tumorigenic effect of this drug was observed in a 24-month study. During the study in Sprague-Dawley a few rats receiving doses of finasteride up to 160 mg with their daily males and 320 mg every day in females.

However, these doses produced particular systemic exposure of this drug in rats of 888 and 2192 times. Although those observed in some men who take the recommended human dose of 1 mg every day. Therefore all calculations of these exposures were based on calculated AUC for animals and the mean AUC for the man patients.

Therefore in a 19 months long carcinogenicity study into the rats. There is a statistically notable increase in the number of testicular Leydig cell adenomas was seen at 1824 times in human exposure. Although in mice it was 184 times more than human exposure. That is estimated and in rats, at 312 times more than the human exposure an improvement in the number of Leydig cell hyperplasia was observed.

A positive correlation among the proliferative changes in the Leydig cells and an increment in serum LH levels approx 2- to 3-fold over control has been confirmed in both rodent species treated with powerful doses of finasteride. However, no drug-related Leydig cell changes were observed in either rats or dogs, who were treated with the help of finasteride for 1 year at 240 and 2800 times. Besides that, in mice who treated for 19 months at 18.4 times then the human exposure estimated.

However, no proof of mutagenicity was noted in a mammalian cell mutagenesis assay, an in vitro bacterial mutagenesis assay, or in an in vitro alkaline elution assay. In an in vitro chromosome aberration assay, utilizing Chinese hamster ovary cells. Hence there was a slight increment in chromosome aberrations.

Although in an in vivo chromosome aberration assay in mice, there is no treatment-related improvement in chromosome aberration was noted with finasteride at the peak tolerated dose of 250 mg every day, which is 1824 times then the human exposure as defined in the carcinogenicity studies.

However, in sexually mature male rabbits who are treated with finasteride at 4344 times then the human exposure for up to 12 weeks of time. There was no effect on sperm count, fertility, or ejaculate volume was observed. In sexually developed male rats who treated with 488 times than in human exposure. Although there were no notable effects on their fertility after 6 or 12 weeks duration of treatment.

However, when the treatment was continued for a long time up to 24 or 30 weeks. There was an obvious reduction in fecundity, fertility, and an associated notable reduction in the weights of the prostate and the seminal vesicles. All these impacts were reversible within the 6 weeks of duration on discontinuation of the medication.

Although no drug-related impact on testes or on mating performance has been observed in rats or rabbits. Hence this reduction in fertility within finasteride-treated rats is secondary to its impact on accessory sex organs known as prostate and seminal vesicles. This resulting in the failure to form a seminal plug. However, the seminal plug is very necessary for natural fertility in rats, but it is not relevant in man.

However, Propecia is contraindicated for treatment in women who are currently or may become pregnant. Because Propecia is a Type II 5α-reductase inhibitor. Hence it can prevent the conversion of testosterone into 5α-dihydrotestosterone (DHT). Basically, it is a hormone that is necessary for the normal development of male genitalia.

Basically in animal studies, finasteride produced abnormal growth of external genitalia in male fetuses. If this medication is used during the pregnancy, or if the patient becomes pregnant by chance while using this medicine, the patient should be informed of the possible hazard to the male fetus.

In addition, some abnormal male genital growth is an expected consequence, when the transformation of testosterone to 5α- dihydrotestosterone (DHT) is inhibited by 5α-reductase inhibitors. Although these results are similar to those reported in male newborns with genetic 5α-reductase deficiency.

Women could be exposed to finasteride through contact with crushed or broken Propecia tablets or semen from a male partner taking PROPECIA. With regard to finasteride exposure through the skin, Propecia tablets are coated and will prevent skin contact with finasteride during normal handling if the tablets have not been crushed or broken.

Also, those women who may become pregnant or are pregnant currently, should not handle damaged or fragmented Propecia medicines. Because of the potential danger of a male fetus. When a pregnant woman gets in contact with crushed or broken Propecia tablets.

Then the touched area of skin must be washed immediately with water and soap. Because with consideration to potential finasteride vulnerability through semen, a study has been carried out in men taking Propecia 1 mg every day that marked finasteride concentrations in the semen of men.

In a study of embryo-fetal development, some pregnant rats got finasteride through the period of major organogenesis or gestation days 6 to 17. At the maternal doses of finasteride oral drug approximately 1 to 684 times than the recommended human dose (RHD) which is 1 mg every day. So there was a dose-dependent increment in hypospadias which occurred in 3.6 to 100% of male offspring.

However, multiples exposure was estimated using the data from the nonpregnant rats. Therefore days 16 to 17 of gestation is a significant period in male fetal rats for differentiation of the outer genitalia. Although at oral maternal doses approximately 0.2 times the RHD, male offspring had reduced prostatic and seminal vesicular weights, delayed preputial division, and transient nipple development.

Reduced anogenital distance happened in the male offspring of pregnant rats that acquired approximately 0.02 times the RHD. However, no abnormalities were seen in female offspring exposed to any dose of finasteride in utero.

Also, No developmental irregularities were seen in the offspring of untreated females when mated with finasteride-treated male rats, that got approximately 488 times the RHD. Then slightly reduced fertility was seen in male offspring after treatment of about 20 times the RHD to female rats while late gestation and lactation. No impacts on fertility were observed in female offspring under certain conditions.

However, no sign of male external genital abnormalities or other irregularities were observed in rabbit fetuses exposed to finasteride through the period of major organogenesis ( such as gestation days 6-18) at maternal doses of this drug up to 100 mg every day. Although finasteride disclosure levels were not measured in rabbits. However, this study may not have combined the critical period for finasteride impacts on the development of male outer genitalia in the rabbit.

The fetal impacts of maternal finasteride exposure through the period of embryonic and fetal development were estimated in the rhesus monkey (on the gestation days 20-100), in a species and growth period more predictive of specific impacts in humans than the studies in rabbits and rats.

Intravenous administration of finasteride drug to the pregnant monkeys at doses as high as 800 ng every day. That measured maximal blood concentration of 1.86 ng/mL or approximately 930 times then the highest estimated exposure of pregnant women to finasteride from semen of men taking 1 mg every day, Then it resulted in no abnormalities in male fetuses.

However, in acceptance of the relevance of the rhesus model for human fetal progress, oral administration of a dose of finasteride, approximately 2 mg every day or approximately 120,000 times then the highest evaluated blood levels of finasteride drug from semen of men using 1 mg every day. That to pregnant monkeys produced in external genital irregularities in male fetuses. Although no other irregularities were seen in male fetuses and no finasteride drug-related irregularities were seen in female fetuses at any dose.

Some other important effects of this drug or the usages are given below:

Nursing Mothers: Profecia drug is not meant for usage in women. It is not known whether finasteride drug is excreted in human milk or not.

Pediatric Use: Profecia medication is not designated for application in pediatric patients. Although the safety and effectiveness of this drug in pediatric patients have not been confirmed.

Geriatric Use: However, some clinical effectiveness studies with Profecia did not involve subjects aged between 65 and above. Although based on the pharmacokinetics of finasteride 5 mg drug, no adjustment of dosage is required for the elderly for Profecia. However, the effectiveness of Profecia in the elderly has not been established.

Hepatic Impairment: Although caution must be exercised in the administration of Profecia in such patients who come with some liver function irregularities, as finasteride drug is metabolized largely in the liver.

Renal Impairment: However, no adjustment of the dosage is required for those patients who are with some renal impairment.

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